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Quantitative CEST with BIRDS

D. Coman, G. Kiefer, D. L. Rothman, D. A. Sherry, and F. Hyder Diagnostic Radiology, Yale University, New Haven, CT, United States, Quantitative Neuroscience with Magnetic Resonance (QNMR), Yale University, New Haven, CT, United States, Macrocyclics, Dallas, TX, United States, Diagnostic Radiology and Biomedical Engineering, Yale University, New Haven, CT, United States, Advanced Imaging Resear...

Cest / Wiener Neustadt Bioelectrochemistry and More

Pressure Dependent Signal Enhancement in Hyper-CEST

Introduction The so called hyper-CEST method promises tremendous potential on molecule-specific MR imaging using hyperpolarized Xe caged in functionalized cryptophane cages [1]. It was shown that these biosensors can be utilized as highly sensitive temperature probes [2] and that molecule-specific signals in the lower nM regime can be detected when experimental parameters are optimized to yield...

The Pursuit of Theranostics with CEST MRI

Molecular imaging has often provided tantalizing potential for tracking theranostic agents during in vivo studies. Each in vivo imaging modality has its limitations, which has impeded the application of molecular imaging towards theranostics research. For example, Magnetic Resonance Spectroscopy (MRS) has been used to detect drug delivery with great molecular specificity due to the unique MR fr...

Detection of Glycosaminoglycans using Positive CEST approach

Introduction CEST contrast employs Chemical Exchange Saturation Transfer to generate contrast in MRI images. It is based on the selective presaturation of the small pool of exchanging protons and can be switched "on" and "off" using suitable RF irradiation (1). Recently, CEST was applied to detect glycosaminoclycans (GAGs) in articular cartilage and intervertebral disc. This method was called g...